A US research station, Antarctica, early-winter 1982. The base is suddenly buzzed by a helicopter from the nearby Norwegian research station. They are trying to kill a dog that has escaped from their base. After the destruction of the Norwegian chopper the members of the US team fly to the Norwegian base, only to discover them all dead or missing. They do find the remains of a strange creature the Norwegians burned. The Americans take it to their base and deduce that it is an alien life form. After a while it is apparent that the alien can take over and assimilate into other life forms, including humans, and can spread like a virus. This means that anyone at the base could be inhabited by The Thing, and tensions escalate.

In NYC's Chinatown, recluse math genius Max (Sean Gullette) believes "everything can be understood in terms of numbers," and he looks for a pattern in the system as he suffers headaches, plays Go with former teacher Sol Robeson (Mark Margolis), and fools around with an advanced computer system he's built in his apartment. Both a Wall Street company and a Hasidic sect take an interest in his work, but he's distracted by blackout attacks, hallucinations, and paranoid delusions..

In the late 1960s, just for a lark, graduate student Eddie Jessup, known for being unconventional, brilliant and slightly mad, conducts experiments with an isolation chamber, using himself as the subject. His experiences in the chamber cause him to hallucinate, much of the imagery being religious-based although he's not religious. Seven years later, he is a respected full professor in the Harvard Medical School. Believing he has lost his edge and fallen into an unwanted state of respectability, Eddie decides to resume his work with sensory deprivation, this time using hallucinogens, specifically untested ones used in mystical Mexican rituals, to enhance the isolation-take experience. After initial tests, he claims he entered an alternate physical and mental state. Although unbelieving of Eddie's claims, his colleagues Arthur Rosenberg and Mason Parrish, as well as Eddie's wife Emily, herself a respected academic, are concerned for Eddie's well being. However, if Eddie's claims are indeed true, he could do irreparable harm to himself and others around him, especially if his altered states are uncontrollable.

Mad with pain by the festering wound in his thigh, an extreme sado-sexual "Metal Fetishist" dashes out into the street, and is accidentally hit by the car of a white-collar worker and his girlfriend. But, strangely, instead of dying, the salaryman finds himself before a mysterious and agonisingly majestic transformation--one that twists and bends the pliable human flesh, inextricably intertwining it with the strong and cold iron. Now, there is no turning back, and nothing can stand in the way of the glorious final mutation. Is this the beginning of a new era?

A film that defies conventional logic and storytelling, fueled by its dark nightmarish atmosphere and compellingly disturbing visuals. Henry Spencer is a hapless factory worker on his vacation when he finds out he's the father of a hideously deformed baby. Now living with his unhappy, malcontent girlfriend, the child cries day and night, driving Henry and his girlfriend to near insanity.

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