Agents Adair, Antoine, Colby, and Trotter both monitor and create chaos across the universe. The sketches seen throughout most of the show are different subjects being monitored. At the end of each episode, all the sketches and characters come together into one final sketch. Besides all the sketches, they have other segments where the UCB Agents venture out with hidden cameras, and try to incorporate the content of their bizarre sketches into the real world.

Misadventures of college freshman Steven Karp, his fellow freshman and first ever girlfriend Lizzie Exley, Steven's self-confidant sophisticated womanizing British college roommate Lloyd Haythe, Lizzie's endearing college roommate with a wild side Rachel Lindquist, Steven's chubby happy-go-lucky college roommate Ron Garner, Steven's weird college roommate Marshall Nesbitt, Lizzie's loving but obsessive ex boyfriend Eric, and Steven's sympathetic geeky dad, who's just been dumped by Steven's mom which triggered his midlife crisis.

Alvey and Lisa are struggling to keep their gym, Navy Street, afloat. Their best hope is Alvey's son Nate, an up and coming fighter. Jay, Alvey's other son, is on the outs with his father. When Lisa's ex and former MMA champ, Ryan, shows up, complications arise. Nate has secrets of his own which may hold him back.

Plum Kettle is a ghostwriter for the editor of one of New York's hottest fashion magazines. Struggling with self-image and fed up with how she's treated by her boss and society, Plum sets out on a wildly complicated road to self-awakening. At the same time, everyone is buzzing over news reports about men, accused of sexual abuse and assault, who are disappearing and meeting untimely, violent deaths.

Life is really tough for Julie Kessler (Julie Klausner) and Billy Epstein (Billy Eichner), two thirty-something aspiring comics living and working in New York City. While their friends and acquaintances move on to find success and love, they continue to struggle with careers and relationships, getting more bitter by the day.

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