Dr. Edward Pretorius and his assistant, the physician Crawford Tillinghast, have developed the Resonator, a machine to stimulate the sixth sense through the pineal gland. When Crawford activates the apparatus, he sees creatures flying in the air and he summons Dr. Pretorius. The experiment goes out of control and Dr. Pretorius refuses to turn off the Resonator. Meanwhile their neighbor calls the police, and when the police officers arrive, they see Crawford trying to escape from his house and Dr. Pretorius beheaded. Crawford is sent to a mental institution under the supervision of the sadistic Dr. Bloch. However, the prominent psychiatrist Dr. Katherine McMichaels requests the custody of Crawford and Detective Bubba Brownlee that is investigating the case stays with them. Katherine goes with Crawford and Bubba to see the Resonator and turns the machine on. Dr. Pretorius returns in a mutant shape and attacks them, in the beginning of a gore night with weird life forms.

An eccentric scientist changes the world with his teleportation technology: when his experiment seems to be going well, Dr. Seth Brundle tests his machine on himself and he gets fused with the worst kind of pest on Planet Earth; The Fly. What is the price of a man playing God? Only Seth knows.

After an experimental bio-nerve gas is accidentally released at a remote U.S. military base in Texas, those exposed to the gas turn into flesh-eating, mutating zombies out to kill. An assortment of various people who include stripper Cherry, her shady mechanic ex-boyfriend Wray, a strong-willed doctor, the local sheriff, and an assortment of various people must join forces to survive the night as the so-called "sickos" threaten to take over the whole town and the world.

A double-bill of thrillers that recall both filmmakers' favorite exploitation films. "Grindhouse" (a downtown movie theater in disrepair since its glory days as a movie palace known for "grinding out" non-stop double-bill programs of B-movies) is presented as one full-length feature comprised of two individual films helmed separately by each director. "Death Proof," is a rip-roaring slasher flick where the killer pursues his victims with a car rather than a knife, while "Planet Terror" shows us a view of the world in the midst of a zombie outbreak. The films are joined together by clever faux trailers that recall the '50s exploitation drive-in classics.

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